Ionis Pharmaceuticals Stock Alpha and Beta Analysis

IONS Stock  USD 78.97  1.01  1.26%   
This module allows you to check different measures of market premium (i.e., alpha and beta) for all equities such as Ionis Pharmaceuticals. It also helps investors analyze the systematic and unsystematic risks associated with investing in Ionis Pharmaceuticals over a specified time horizon. Remember, high Ionis Pharmaceuticals' alpha is almost always a sign of good performance; however, a high beta will depend on investors' risk tolerance level and may signal increased volatility and potential future overvaluation. Key technical indicators related to Ionis Pharmaceuticals' market risk premium analysis include:
Beta
0.79
Alpha
0.31
Risk
1.89
Sharpe Ratio
0.16
Expected Return
0.31
Please note that although Ionis Pharmaceuticals alpha is a measure of relative return and represented here as a single number, it indicates the percentage above or below your selected benchmark (i.e., Dow Jones Industrial index.) So in this particular case, Ionis Pharmaceuticals did 0.31  better than the index. Remember, a high alpha is always good. Beta, on the other hand, measures the volatility (or risk) of an investment. It is an indication of Ionis Pharmaceuticals stock's relative risk over its benchmark. Ionis Pharmaceuticals has a beta of 0.79  . As returns on the market increase, Ionis Pharmaceuticals' returns are expected to increase less than the market. However, during the bear market, the loss of holding Ionis Pharmaceuticals is expected to be smaller as well. Enterprise Value is likely to gain to about 7.8 B in 2025, whereas Book Value Per Share is likely to drop 2.22 in 2025.

Enterprise Value

7.83 Billion

Alpha is a measure of relative performance on a risk-adjusted basis, while beta measures volatility against the benchmark. The goal is to know if an investor is being compensated for the volatility risk taken. The return on investment might be better than its reference but still not compensate for the assumption of the risk.
Check out Ionis Pharmaceuticals Backtesting, Ionis Pharmaceuticals Valuation, Ionis Pharmaceuticals Correlation, Ionis Pharmaceuticals Hype Analysis, Ionis Pharmaceuticals Volatility, Ionis Pharmaceuticals History and analyze Ionis Pharmaceuticals Performance.
For more information on how to buy Ionis Stock please use our How to Invest in Ionis Pharmaceuticals guide.

Ionis Pharmaceuticals Market Premiums

Investors always prefer to have the highest possible return on investment, coupled with the lowest possible volatility. Ionis Pharmaceuticals market risk premium is the additional return an investor will receive from holding Ionis Pharmaceuticals long position in a well-diversified portfolio. The market premium is part of the Capital Asset Pricing Model (CAPM), which most analysts and investors use to calculate the acceptable rate of return on investment in Ionis Pharmaceuticals. At the center of the CAPM is the concept of risk and reward, which is usually communicated by investors using alpha and beta measures. Alpha and beta are two of the key measurements used to evaluate Ionis Pharmaceuticals' performance over market.
α0.31   β0.79

Ionis Pharmaceuticals expected buy-and-hold returns

Although buy-and-hold investment strategy may not appeal to all investors, it may be used as a good measure of Ionis Pharmaceuticals' Buy-and-hold return. Our buy-and-hold chart shows how Ionis Pharmaceuticals performed over your current time horizon against a typical interest-earning bank account and a selected benchmark.

Ionis Pharmaceuticals Market Price Analysis

Market price analysis indicators help investors to evaluate how Ionis Pharmaceuticals stock reacts to ongoing and evolving market conditions. The investors can use it to make informed decisions about market timing, and determine when trading Ionis Pharmaceuticals shares will generate the highest return on investment. By understating and applying Ionis Pharmaceuticals stock market price indicators, traders can identify Ionis Pharmaceuticals position entry and exit signals to maximize returns.

Ionis Pharmaceuticals Return and Market Media

The median price of Ionis Pharmaceuticals for the period between Wed, Oct 1, 2025 and Tue, Dec 30, 2025 is 73.57 with a coefficient of variation of 6.89. The daily time series for the period is distributed with a sample standard deviation of 5.13, arithmetic mean of 74.51, and mean deviation of 4.26. The Stock received a lot of media exposure during the period.
 Price Growth (%)  
       Timeline  
1
Disposition of 11475 shares by Birchler Brian of Ionis Pharmaceuticals at 53.77 subject to Rule 16b-3
10/14/2025
2
Disposition of 12425 shares by Birchler Brian of Ionis Pharmaceuticals at 53.77 subject to Rule 16b-3
10/15/2025
3
Disposition of 18300 shares by Richard Geary of Ionis Pharmaceuticals at 60.89 subject to Rule 16b-3
11/06/2025
4
Ionis Prices Convertible Notes Offering to Refinance 2026 Convertible Notes
11/13/2025
5
Disposition of 16777 shares by Shannon Devers of Ionis Pharmaceuticals at 53.77 subject to Rule 16b-3
11/25/2025
6
Ionis receives U.S. FDA Breakthrough Therapy designation for olezarsen for severe hypertriglyceridemia
12/01/2025
7
Pharvaris Pill Provides Rapid Relief In Patients With Rare Swelling Attacks, Data Shows
12/03/2025
8
Madrigal Up 21.9 percent Since Last Earnings Report Can It Continue
12/04/2025
9
Is Invesco RAFI US 1500 Small-Mid ETF a Strong ETF Right Now
12/08/2025
10
Ionis Pharmaceuticals Price Target Raised to 97.00
12/12/2025
11
How New Deals and Diverging Analyst Views Are Rewriting the Story for AstraZeneca
12/15/2025
12
Ionis Pharmaceuticals Revisiting Valuation After a Powerful Year-to-Date Share Price Rally
12/19/2025
13
Is VanEck Morningstar SMID Moat ETF a Strong ETF Right Now
12/29/2025
14
Disposition of 30203 shares by Oneil Patrick R. of Ionis Pharmaceuticals at 56.78 subject to Rule 16b-3
12/30/2025

About Ionis Pharmaceuticals Beta and Alpha

For many years both, Alpha and Beta indicators are used by professional money managers as critical performance measurement tools across virtually all financial instruments including Ionis or other stocks. Alpha measures the amount that position in Ionis Pharmaceuticals has returned in comparison to a selected market index or another relevant benchmark. In other words, Alpha is the excess return on an investment relative to the performance of your selected benchmark. Beta, on the other hand, measures the relative risk of your investment.
 2022 2023 2024 2025 (projected)
Days Sales Outstanding15.8745.3147.7245.33
PTB Ratio9.3518.718.888.44

Ionis Pharmaceuticals Upcoming Company Events

As portrayed in its financial statements, the presentation of Ionis Pharmaceuticals' financial position is often influenced by management's estimates, judgments, and sometimes even manipulations. In the best case, Ionis Pharmaceuticals' leadership is honest, while the outside auditors are strict and uncompromising. Whatever the case, investors should always follow all of Ionis Pharmaceuticals' public filing events to personally review all filings and be reasonable and skeptical to interpret all of the financial statements of Ionis Pharmaceuticals. Please utilize our Beneish M Score to check the likelihood of Ionis Pharmaceuticals' management manipulating its earnings.
28th of February 2024
Upcoming Quarterly Report
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1st of May 2024
Next Financial Report
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31st of December 2023
Next Fiscal Quarter End
View
28th of February 2024
Next Fiscal Year End
View
30th of September 2023
Last Quarter Report
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31st of December 2022
Last Financial Announcement
View

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Additional Tools for Ionis Stock Analysis

When running Ionis Pharmaceuticals' price analysis, check to measure Ionis Pharmaceuticals' market volatility, profitability, liquidity, solvency, efficiency, growth potential, financial leverage, and other vital indicators. We have many different tools that can be utilized to determine how healthy Ionis Pharmaceuticals is operating at the current time. Most of Ionis Pharmaceuticals' value examination focuses on studying past and present price action to predict the probability of Ionis Pharmaceuticals' future price movements. You can analyze the entity against its peers and the financial market as a whole to determine factors that move Ionis Pharmaceuticals' price. Additionally, you may evaluate how the addition of Ionis Pharmaceuticals to your portfolios can decrease your overall portfolio volatility.