Is Karyopharm Therapeutics Stock a Good Investment?

Karyopharm Therapeutics Investment Advice

  KPTI
To provide specific investment advice or recommendations on Karyopharm Therapeutics stock, we recommend investors consider the following general factors when evaluating Karyopharm Therapeutics. This will help you to make an informed decision on whether to include Karyopharm Therapeutics in one of your diversified portfolios:
  • Examine Karyopharm Therapeutics' financial health by looking at its balance sheet, income statement, and cash flow statement. Analyze key financial ratios, such as Price-to-Earnings (P/E), Price-to-Sales (P/S), and Price-to-Book (P/B), to determine whether the stock is fairly valued or over/undervalued.
  • Research Karyopharm Therapeutics' leadership team and their track record. Good management can help Karyopharm Therapeutics navigate difficult times and make strategic decisions that benefit shareholders and increases its net worth.
  • Consider the overall health of the Biotechnology space and any emerging trends that could impact Karyopharm Therapeutics' business and its evolving consumer preferences.
  • Compare Karyopharm Therapeutics' performance and market position to its competitors. Analyze how Karyopharm Therapeutics is positioned in terms of product offerings, innovation, and market share.
  • Check if Karyopharm Therapeutics pays a dividend and its dividend yield and payout ratio.
  • Review what financial analysts are saying about Karyopharm Therapeutics' stock and their price targets. However, remember that analysts' opinions can vary, and their predictions may not always be accurate.
It's important to note that investing in Karyopharm Therapeutics stock, carries risks, and you should carefully consider your investment goals and risk tolerance before making any investment decisions. Also, remember that it's important for investors to have a long-term perspective and a well-diversified portfolio to manage the impact of stock market volatility on their investments. Below is a detailed guide on how to decide if Karyopharm Therapeutics is a good investment.
 
Sell
 
Buy
Sell
We provide investment recommendation to complement the last-minute expert consensus on Karyopharm Therapeutics. Our dynamic recommendation engine harnesses a multidimensional algorithm to analyze the entity's potential to grow using all technical and fundamental data available at the time. To make sure Karyopharm Therapeutics is not overpriced, please verify all Karyopharm Therapeutics fundamentals, including its revenue, cash flow from operations, working capital, as well as the relationship between the cash per share and number of employees . Given that Karyopharm Therapeutics has a price to earning of (3.90) X, we recommend you to check Karyopharm Therapeutics market performance and probability of bankruptcy to ensure the company can sustain itself in the current economic cycle given your last-minute risk tolerance and investing horizon.

Market Performance

Very WeakDetails

Volatility

Very riskyDetails

Hype Condition

Over hypedDetails

Current Valuation

UndervaluedDetails

Odds Of Distress

Very HighDetails

Economic Sensitivity

Slowly supersedes the marketDetails

Investor Sentiment

AlarmedDetails

Analyst Consensus

Strong BuyDetails

Financial Strenth (F Score)

FrailDetails

Financial Leverage

Not RatedDetails

Reporting Quality (M-Score)

Unlikely ManipulatorDetails

Examine Karyopharm Therapeutics Stock

Researching Karyopharm Therapeutics' stock involves analyzing various aspects of the company and its industry to make an informed investment decision. The key areas to focus on are fundamentals, business model and competitive advantage. It is also important to analyze trends in revenue, net income, and cash flow, as well as key financial ratios, such as price-to-earnings (P/E), price-to-sales (P/S), and debt-to-equity (D/E). About 48.0% of the company shares are owned by institutional investors. The company recorded a loss per share of 13.95. Karyopharm Therapeutics had not issued any dividends in recent years. The entity had 1:15 split on the 26th of February 2025.
To determine if Karyopharm Therapeutics is a good investment, evaluating the company's potential for future growth is also very important. This may include expanding into new markets, launching new products or services, or improving operational efficiency. Companies with strong growth prospects can be more attractive investments. This aspect of the research should be conducted in the context of the overall market and industry in which the company operates and should include an analysis of growth potential, competitive landscape, and any regulatory or economic factors that could impact the business. Some of the essential points regarding Karyopharm Therapeutics' research are outlined below:
Karyopharm Therapeutics generated a negative expected return over the last 90 days
Karyopharm Therapeutics has high historical volatility and very poor performance
Karyopharm Therapeutics has a very high chance of going through financial distress in the upcoming years
The company reported the previous year's revenue of 145.24 M. Net Loss for the year was (76.42 M) with profit before overhead, payroll, taxes, and interest of 139.23 M.
Karyopharm Therapeutics currently holds about 170.85 M in cash with (127.49 M) of positive cash flow from operations. This results in cash-per-share (CPS) ratio of 2.14.
Karyopharm Therapeutics has a frail financial position based on the latest SEC disclosures
Latest headline from news.google.com: Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635 - PR Newswire
Karyopharm Therapeutics uses earnings reports to provide investors with an update of all three financial statements, including the income statement, the balance sheet, and the cash flow statement. Therefore, it is also crucial when considering investing in Karyopharm Therapeutics. Every quarterly earnings report provides investors with an overview of sales, expenses, and net income for the most recent period. It also may provide a comparison to Karyopharm Therapeutics' previous reporting period. The quarterly earnings reports are usually disseminated to the public via Form 10-Q, which is a legal document filed with the Securities and Exchange Commission every quarter.
21st of February 2024
Upcoming Quarterly Report
View
2nd of May 2024
Next Financial Report
View
31st of December 2023
Next Fiscal Quarter End
View
21st of February 2024
Next Fiscal Year End
View
30th of September 2023
Last Quarter Report
View
31st of December 2022
Last Financial Announcement
View
Earnings surprises can significantly impact Karyopharm Therapeutics' stock price both in the short term and over time. Negative earnings surprises usually result in a price decline. However, it has been seen that positive earnings surprises lead to an immediate rise in a stock's price and a gradual increase over time. This is why we often hear news about some companies beating earning projections. Financial analysts spend a large amount of time predicting earnings per share (EPS) along with other important future indicators. Many analysts use forecasting models, management guidance, and additional fundamental information to derive an EPS estimate. Below are the table of largest EPS Surprises Karyopharm Therapeutics' investors have experienced.
Reported
Fiscal Date
Estimated EPS
Reported EPS
Surprise
2025-02-26
2024-12-31-0.2688-0.240.028810 
2024-02-29
2023-12-31-0.31-0.36-0.0516 
2023-08-02
2023-06-30-0.34-0.290.0514 
2014-08-07
2014-06-30-0.49-0.55-0.0612 
2023-05-04
2023-03-31-0.37-0.30.0718 
2023-02-15
2022-12-31-0.35-0.43-0.0822 
2016-08-04
2016-06-30-0.76-0.84-0.0810 
2020-05-05
2020-03-31-0.69-0.78-0.0913 

Karyopharm Therapeutics Target Price Consensus

Karyopharm target price is determined by taking all analyst projections and averaging them out. There is no one specific way to measure analysts' performance other than comparing it to past results via a very sophisticated attribution analysis. Karyopharm Therapeutics' target price projections below should be used in combination with other traditional price prediction techniques such as stock price forecasting, investor sentiment analysis, technical analysis, earnings estimate, and various momentum models.
   7  Strong Buy
Most Karyopharm analysts issue ratings four times a year, at intervals of three months. Ratings are usually accompanied by a target price to help potential investors understand Karyopharm stock's fair price compared to its market value. Analysts arrive at stock ratings after researching the public financial statements of Karyopharm Therapeutics, talking to its executives and customers, or listening to those companies' conference calls.
Macroaxis Advice   Exposure   Valuation

Karyopharm Therapeutics Target Price Projection

Karyopharm Therapeutics' current and average target prices are 4.10 and 4.50, respectively. The current price of Karyopharm Therapeutics is the price at which Karyopharm Therapeutics is currently trading. On the other hand, Karyopharm Therapeutics' target price is what analysts think the stock is worth or could sell for in the future. The more significant the discrepancy between the two prices, the more it stimulates investors to act.

Current Price

Karyopharm Therapeutics Market Quote on 7th of April 2025

Low Price3.51Odds
High Price4.1Odds

4.1

Target Price

Analyst Consensus On Karyopharm Therapeutics Target Price

Low Estimate4.1Odds
High Estimate5.0Odds

4.5

Historical Lowest Forecast  4.1 Target Price  4.5 Highest Forecast  5.0
Note that most analysts generally publish their price targets in research reports on specific companies, along with recommendations for the company's stock.Although price targets are often quoted in the financial news media, there could be a delay between the publication of the latest analyst outlook on Karyopharm Therapeutics and the information provided on this page.

Karyopharm Therapeutics Analyst Ratings

Karyopharm Therapeutics' analyst stock recommendations are determined by taking an average estimate of all analysts we track and classifying them as Strong Buy, Buy, Hold, Strong Sell, or Sell. Ratings generally communicate what analysts sense about Karyopharm Therapeutics stock, and they use a lot of effort and time to analyze it and arrive at a rating. That suggests that analyst recommendations are the outcome of an objective and thorough examination of Karyopharm Therapeutics' financials, market performance, and future outlook by experienced professionals. Karyopharm Therapeutics' historical ratings below, therefore, can serve as a valuable tool for investors.

Know Karyopharm Therapeutics' Top Institutional Investors

Have you ever been surprised when a price of an equity instrument such as Karyopharm Therapeutics is soaring high without any particular reason? This is usually happening because many institutional investors are aggressively trading Karyopharm Therapeutics backward and forwards among themselves. Karyopharm Therapeutics' institutional investor refers to the entity that pools money to purchase Karyopharm Therapeutics' securities or originate loans. Institutional investors include commercial and private banks, credit unions, insurance companies, pension funds, hedge funds, endowments, and mutual funds. Operating companies that invest excess capital in these types of assets may also be included in the term and may influence corporate governance by exercising voting rights in their investments.
Shares
Cam Group Holding A/s2024-12-31
1.5 M
Ubs O'connor Llc2024-12-31
1.5 M
Geode Capital Management, Llc2024-12-31
1.4 M
Goldman Sachs Group Inc2024-12-31
1.3 M
Bnp Paribas Arbitrage, Sa2024-12-31
1.3 M
Deutsche Bank Ag2024-12-31
1.3 M
Renaissance Technologies Corp2024-12-31
1.2 M
Kennedy Capital Management Inc2024-12-31
1.2 M
Millennium Management Llc2024-12-31
1.2 M
Vanguard Group Inc2024-12-31
7.7 M
Adage Capital Partners Gp Llc2024-12-31
6.3 M
Note, although Karyopharm Therapeutics' institutional investors appear to be way more sophisticated than retail investors, it remains unclear if professional active investment managers can reliably enhance risk-adjusted returns by an amount that exceeds fees and expenses.

Karyopharm Therapeutics' market capitalization trends

The company currently falls under 'Micro-Cap' category with a current market capitalization of 32.49 M.

Market Cap

4.49 Billion

Karyopharm Therapeutics' profitablity analysis

Last ReportedProjected for Next Year
Return On Tangible Assets(0.46)(0.49)
Return On Capital Employed(1.66)(1.57)
Return On Assets(0.46)(0.49)
Return On Equity 0.41  0.43 
The company has Profit Margin (PM) of (0.53) %, which may suggest that it does not properly executes on its current pricing strategies or is unable to control all of the operational costs. This is way below average. Similarly, it shows Operating Margin (OM) of (1.02) %, which suggests for every $100 dollars of sales, it generated a net operating loss of $1.02.
Determining Karyopharm Therapeutics' profitability involves analyzing its financial statements and using various financial metrics to determine if Karyopharm Therapeutics is a good buy. For example, gross profit margin measures Karyopharm Therapeutics' profitability after accounting for the cost of goods sold, while net profit margin measures profitability after accounting for all expenses. Other important metrics include return on assets, return on equity, and free cash flow. By reviewing multiple sources and metrics, you can gain a complete picture of Karyopharm Therapeutics' profitability and make more informed investment decisions.

Evaluate Karyopharm Therapeutics' management efficiency

Karyopharm Therapeutics has return on total asset (ROA) of (0.3688) % which means that it has lost $0.3688 on every $100 spent on assets. This is way below average. Similarly, it shows a return on stockholder's equity (ROE) of (8.9105) %, meaning that it created substantial loss on money invested by shareholders. Karyopharm Therapeutics' management efficiency ratios could be used to measure how well Karyopharm Therapeutics manages its routine affairs as well as how well it operates its assets and liabilities. The Karyopharm Therapeutics' current Return On Equity is estimated to increase to 0.43, while Return On Tangible Assets are projected to decrease to (0.49). As of now, Karyopharm Therapeutics' Total Assets are increasing as compared to previous years. The Karyopharm Therapeutics' current Total Current Assets is estimated to increase to about 212.5 M, while Non Current Assets Total are projected to decrease to under 7.5 M.
Last ReportedProjected for Next Year
Book Value Per Share(1.53)(1.45)
Tangible Book Value Per Share(1.53)(1.45)
Enterprise Value Over EBITDA(32.98)(34.63)
Price Book Value Ratio(6.64)(6.31)
Enterprise Value Multiple(32.98)(34.63)
Price Fair Value(6.64)(6.31)
Enterprise Value5.9 B4.4 B
Understanding the operational decisions made by Karyopharm Therapeutics management offers insights into its financial robustness. This evaluation is crucial for assessing the stock's investment potential.
Beta
0.586

Basic technical analysis of Karyopharm Stock

As of the 7th of April, Karyopharm Therapeutics secures the Standard Deviation of 6.78, risk adjusted performance of (0.22), and Mean Deviation of 5.04. Karyopharm Therapeutics technical analysis lets you operate historical price patterns with an objective to determine a pattern that forecasts the direction of the firm's future prices.

Karyopharm Therapeutics' insider trading activities

Some recent studies suggest that insider trading raises the cost of capital for securities issuers and decreases overall economic growth. Trading by specific Karyopharm Therapeutics insiders, such as employees or executives, is commonly permitted as long as it does not rely on Karyopharm Therapeutics' material information that is not in the public domain. Local jurisdictions usually require such trading to be reported in order to monitor insider transactions. In many U.S. states, trading conducted by corporate officers, key employees, directors, or significant shareholders must be reported to the regulator or publicly disclosed, usually within a few business days of the trade. In these cases Karyopharm Therapeutics insiders are required to file a Form 4 with the U.S. Securities and Exchange Commission (SEC) when buying or selling shares of their own companies.
 
Mano Michael over a week ago
Acquisition by Mano Michael of 9167 shares of Karyopharm Therapeutics subject to Rule 16b-3
 
Mirza Mansoor Raza over three weeks ago
Acquisition by Mirza Mansoor Raza of 69000 shares of Karyopharm Therapeutics at 0.96 subject to Rule 16b-3
 
Mano Michael over a month ago
Disposition of 2793 shares by Mano Michael of Karyopharm Therapeutics at 6.29 subject to Rule 16b-3
 
Mano Michael over a month ago
Acquisition by Mano Michael of 4500 shares of Karyopharm Therapeutics at 7.95 subject to Rule 16b-3
 
Paulson Richard A. over two months ago
Disposition of 4099 shares by Paulson Richard A. of Karyopharm Therapeutics at 0.65 subject to Rule 16b-3
 
Macomber Lori over two months ago
Acquisition by Macomber Lori of 160000 shares of Karyopharm Therapeutics subject to Rule 16b-3
 
Paulson Richard A. over three months ago
Disposition of 4055 shares by Paulson Richard A. of Karyopharm Therapeutics at 0.783 subject to Rule 16b-3
 
Macomber Lori over three months ago
Insider Trading
 
Paulson Richard A. over three months ago
Disposition of 3592 shares by Paulson Richard A. of Karyopharm Therapeutics at 0.99 subject to Rule 16b-3
 
Su Zhen over three months ago
Acquisition by Su Zhen of 68000 shares of Karyopharm Therapeutics at 1.28 subject to Rule 16b-3
 
Cheng Sohanya Roshan over three months ago
Disposition of 5109 shares by Cheng Sohanya Roshan of Karyopharm Therapeutics at 1.2 subject to Rule 16b-3
 
Paulson Richard A. over six months ago
Disposition of 3607 shares by Paulson Richard A. of Karyopharm Therapeutics at 0.8793 subject to Rule 16b-3

Karyopharm Therapeutics' Outstanding Corporate Bonds

Karyopharm Therapeutics issues bonds to finance its operations. Corporate bonds make up one of the largest components of the U.S. bond market, which is considered the world's largest securities market. Karyopharm Therapeutics uses the proceeds from bond sales for a wide variety of purposes, including financing ongoing mergers and acquisitions, buying new equipment, investing in research and development, buying back their own stock, paying dividends to shareholders, and even refinancing existing debt. Most Karyopharm bonds can be classified according to their maturity, which is the date when Karyopharm Therapeutics has to pay back the principal to investors. Maturities can be short-term, medium-term, or long-term (more than ten years). Longer-term bonds usually offer higher interest rates but may entail additional risks.

Understand Karyopharm Therapeutics' technical and predictive indicators

Using predictive indicators to make investment decisions involves analyzing Karyopharm Therapeutics' various financial and market-based factors to help forecast future trends and identify investment opportunities. Select the indicators that are most relevant to your investment strategy. Each indicator has its own strengths and weaknesses, so it's essential to combine multiple indicators to get a more comprehensive view of the market and reduce the risk of making poor decisions based on limited data.

Consider Karyopharm Therapeutics' intraday indicators

Karyopharm Therapeutics intraday indicators are useful technical analysis tools used by many experienced traders. Just like the conventional technical analysis, daily indicators help intraday investors to analyze the price movement with the timing of Karyopharm Therapeutics stock daily movement. By combining multiple daily indicators into a single trading strategy, you can limit your risk while still earning strong returns on your managed positions.

Karyopharm Therapeutics Corporate Filings

F4
6th of March 2025
The report filed by a party regarding the acquisition or disposition of a company's common stock, as well as derivative securities such as options, warrants, and convertible securities
ViewVerify
8K
24th of February 2025
Report filed with the SEC to announce major events that shareholders should know about
ViewVerify
12th of February 2025
Other Reports
ViewVerify
F3
6th of January 2025
The report used by insiders such as officers, directors, and major shareholders (beneficial owners holding more than 10% of any class of the company's equity securities) to declare their ownership of a company's stock
ViewVerify
Karyopharm Therapeutics time-series forecasting models is one of many Karyopharm Therapeutics' stock analysis techniques aimed to predict future share value based on previously observed values. Time-series forecasting models ae widely used for non-stationary data. Non-stationary data are called the data whose statistical properties e.g. the mean and standard deviation are not constant over time but instead, these metrics vary over time. These non-stationary Karyopharm Therapeutics' historical data is usually called time-series. Some empirical experimentation suggests that the statistical forecasting models outperform the models based exclusively on fundamental analysis to predict the direction of the market movement and maximize returns from investment trading.

Karyopharm Stock media impact

Far too much social signal, news, headlines, and media speculation about Karyopharm Therapeutics that are available to investors today. That information is available publicly through Karyopharm media outlets and privately through word of mouth or via Karyopharm internal channels. However, regardless of the origin, that massive amount of Karyopharm data is challenging to quantify into actionable patterns, especially for investors that are not very sophisticated with ever-evolving tools and techniques used in the investment management field.
A primary focus of Karyopharm Therapeutics news analysis is to determine if its current price reflects all relevant headlines and social signals impacting the current market conditions. A news analyst typically looks at the history of Karyopharm Therapeutics relative headlines and hype rather than examining external drivers such as technical or fundamental data. It is believed that price action tends to repeat itself due to investors' collective, patterned thinking related to Karyopharm Therapeutics' headlines and news coverage data. This data is often completely overlooked or insufficiently analyzed for actionable insights to drive Karyopharm Therapeutics alpha.

Karyopharm Therapeutics Sentiment by Major News Outlets

Investor sentiment, mood or attitude towards Karyopharm Therapeutics can have a significant impact on its stock price or the market as a whole. This sentiment can be positive or negative, and various factors, such as economic indicators, news events, or market trends, can influence it. When investor sentiment is positive, investors are more likely to buy stocks, increasing demand and increasing the stock price. Positive investor sentiment can be driven by good news about the company or the broader market, such as solid earnings reports or positive economic data.
Note that negative investor sentiment can cause investors to sell stocks, leading to a decrease in demand and a drop in the stock price. Negative sentiment can be driven by factors such as poor earnings reports, negative news about the company or industry, or broader economic concerns. It's important to note that investor sentiment is just one of many factors that can affect stock prices. Other factors, such as company performance, industry trends, and global economic conditions, can also play a significant role in determining the value of a stock.

Karyopharm Therapeutics Corporate Management

Reshma MDChief VPProfile
Kristin AbateChief VPProfile
James JDChief OfficerProfile
Lisa DiPaoloExecutive OfficerProfile
Sohanya MBAExecutive OfficerProfile
When determining whether Karyopharm Therapeutics offers a strong return on investment in its stock, a comprehensive analysis is essential. The process typically begins with a thorough review of Karyopharm Therapeutics' financial statements, including income statements, balance sheets, and cash flow statements, to assess its financial health. Key financial ratios are used to gauge profitability, efficiency, and growth potential of Karyopharm Therapeutics Stock. Outlined below are crucial reports that will aid in making a well-informed decision on Karyopharm Therapeutics Stock:
Check out Correlation Analysis to better understand how to build diversified portfolios, which includes a position in Karyopharm Therapeutics. Also, note that the market value of any company could be closely tied with the direction of predictive economic indicators such as signals in estimate.
For more detail on how to invest in Karyopharm Stock please use our How to Invest in Karyopharm Therapeutics guide.
You can also try the Portfolio Holdings module to check your current holdings and cash postion to detemine if your portfolio needs rebalancing.
Is Biotechnology space expected to grow? Or is there an opportunity to expand the business' product line in the future? Factors like these will boost the valuation of Karyopharm Therapeutics. If investors know Karyopharm will grow in the future, the company's valuation will be higher. The financial industry is built on trying to define current growth potential and future valuation accurately. All the valuation information about Karyopharm Therapeutics listed above have to be considered, but the key to understanding future value is determining which factors weigh more heavily than others.
Earnings Share
(13.95)
Revenue Per Share
17.877
Quarterly Revenue Growth
(0.1)
Return On Assets
(0.37)
Return On Equity
(8.91)
The market value of Karyopharm Therapeutics is measured differently than its book value, which is the value of Karyopharm that is recorded on the company's balance sheet. Investors also form their own opinion of Karyopharm Therapeutics' value that differs from its market value or its book value, called intrinsic value, which is Karyopharm Therapeutics' true underlying value. Investors use various methods to calculate intrinsic value and buy a stock when its market value falls below its intrinsic value. Because Karyopharm Therapeutics' market value can be influenced by many factors that don't directly affect Karyopharm Therapeutics' underlying business (such as a pandemic or basic market pessimism), market value can vary widely from intrinsic value.
In summary, please note that there is a difference between Karyopharm Therapeutics' value and its price, as these two are different measures arrived at by various means. Investors typically determine if Karyopharm Therapeutics is a good investment by looking at such factors as earnings, sales, fundamental and technical indicators, competition as well as analyst projections. However, Karyopharm Therapeutics' price is the amount at which it trades on the open market and represents the number that a seller and buyer find agreeable to each party.