Denali Therapeutics Stock Alpha and Beta Analysis

DNLI Stock  USD 19.53  0.01  0.05%   
This module allows you to check different measures of market premium (i.e., alpha and beta) for all equities such as Denali Therapeutics. It also helps investors analyze the systematic and unsystematic risks associated with investing in Denali Therapeutics over a specified time horizon. Remember, high Denali Therapeutics' alpha is almost always a sign of good performance; however, a high beta will depend on investors' risk tolerance level and may signal increased volatility and potential future overvaluation. Key technical indicators related to Denali Therapeutics' market risk premium analysis include:
Beta
(0.46)
Alpha
0.61
Risk
3.75
Sharpe Ratio
0.11
Expected Return
0.39
Please note that although Denali Therapeutics alpha is a measure of relative return and represented here as a single number, it indicates the percentage above or below your selected benchmark (i.e., Dow Jones Industrial index.) So in this particular case, Denali Therapeutics did 0.61  better than the index. Remember, a high alpha is always good. Beta, on the other hand, measures the volatility (or risk) of an investment. It is an indication of Denali Therapeutics stock's relative risk over its benchmark. Denali Therapeutics has a beta of 0.46  . As returns on the market increase, returns on owning Denali Therapeutics are expected to decrease at a much lower rate. During the bear market, Denali Therapeutics is likely to outperform the market. As of now, Denali Therapeutics' Book Value Per Share is increasing as compared to previous years. The Denali Therapeutics' current Tangible Book Value Per Share is estimated to increase to 12.90, while Enterprise Value Over EBITDA is forecasted to increase to (5.60).

Enterprise Value

2.17 Billion

Alpha is a measure of relative performance on a risk-adjusted basis, while beta measures volatility against the benchmark. The goal is to know if an investor is being compensated for the volatility risk taken. The return on investment might be better than its reference but still not compensate for the assumption of the risk.
Check out Denali Therapeutics Analysis, Denali Therapeutics Valuation, Denali Therapeutics Correlation, Denali Therapeutics Hype Analysis, Denali Therapeutics Volatility, Denali Therapeutics Price History and analyze Denali Therapeutics Performance.
For more detail on how to invest in Denali Stock please use our How to Invest in Denali Therapeutics guide.

Denali Therapeutics Market Premiums

Investors always prefer to have the highest possible return on investment, coupled with the lowest possible volatility. Denali Therapeutics market risk premium is the additional return an investor will receive from holding Denali Therapeutics long position in a well-diversified portfolio. The market premium is part of the Capital Asset Pricing Model (CAPM), which most analysts and investors use to calculate the acceptable rate of return on investment in Denali Therapeutics. At the center of the CAPM is the concept of risk and reward, which is usually communicated by investors using alpha and beta measures. Alpha and beta are two of the key measurements used to evaluate Denali Therapeutics' performance over market.
α0.61   β-0.46

Denali Therapeutics expected buy-and-hold returns

Although buy-and-hold investment strategy may not appeal to all investors, it may be used as a good measure of Denali Therapeutics' Buy-and-hold return. Our buy-and-hold chart shows how Denali Therapeutics performed over your current time horizon against a typical interest-earning bank account and a selected benchmark.

Denali Therapeutics Market Price Analysis

Market price analysis indicators help investors to evaluate how Denali Therapeutics stock reacts to ongoing and evolving market conditions. The investors can use it to make informed decisions about market timing, and determine when trading Denali Therapeutics shares will generate the highest return on investment. By understating and applying Denali Therapeutics stock market price indicators, traders can identify Denali Therapeutics position entry and exit signals to maximize returns.

Denali Therapeutics Return and Market Media

The median price of Denali Therapeutics for the period between Thu, Nov 13, 2025 and Wed, Feb 11, 2026 is 17.58 with a coefficient of variation of 10.41. The daily time series for the period is distributed with a sample standard deviation of 1.89, arithmetic mean of 18.2, and mean deviation of 1.55. The Stock received a lot of media exposure during the period.
 Price Growth (%)  
       Timeline  
1
Acquisition by Thornberry Nancy of 17901 shares of Denali Therapeutics at 18.56 subject to Rule 16b-3
11/21/2025
2
Denali Therapeutics announces board and leadership changes By Investing.com - Investing.com Nigeria
11/28/2025
3
Does Denali Therapeutics Discounted Equity Raise Reveal a New Phase in Its Risk Strategy
12/16/2025
4
Acquisition by Ryan Watts of 236880 shares of Denali Therapeutics at 16.27 subject to Rule 16b-3
01/02/2026
5
Acquisition by Schuth Alexander O. of 57700 shares of Denali Therapeutics subject to Rule 16b-3
01/05/2026
6
Denali Therapeutics Announces Key Anticipated Milestones and Priorities for 2026 Including Commercial Launch of Tividenofusp Alfa for Hunter Syndrome
01/06/2026
7
Assessing Denali Therapeutics Valuation After Positive Hunter Syndrome Trial Data And FDA Priority Review
01/08/2026
8
Denali Therapeutics Inc. Stock Analysis Exploring An 83 percent Upside Potential - DirectorsTalk Interviews
01/13/2026
9
3 Biotech Stocks That Could Double In 2026 - AOL.com
01/20/2026
10
Acquisition by Klein Peter S of 6037 shares of Denali Therapeutics subject to Rule 16b-3
01/28/2026
11
Denali Therapeutics Announces Data Presentations on Enzyme TransportVehicle Programs for Hunter Syndrome, Sanfilippo Syndrome Type A and Pompe Disease at Upcomi...
01/29/2026
12
Denali Therapeutics To Host Webcast Highlighting Presentations on Enzyme TransportVehicle Programs at the 2026 WORLDSymposium
02/02/2026
13
Denali Therapeutics Presents Enzyme TransportVehicle Progress Across Three Clinical Programs for Treatment of Lysosomal Storage Disorders at 2026 WORLDSymposium
02/05/2026
14
Assessing Denali Therapeutics Valuation After WORLDSymposium Clinical Updates And Regulatory Progress
02/09/2026

About Denali Therapeutics Beta and Alpha

For many years both, Alpha and Beta indicators are used by professional money managers as critical performance measurement tools across virtually all financial instruments including Denali or other stocks. Alpha measures the amount that position in Denali Therapeutics has returned in comparison to a selected market index or another relevant benchmark. In other words, Alpha is the excess return on an investment relative to the performance of your selected benchmark. Beta, on the other hand, measures the relative risk of your investment.
 2023 2025 2026 (projected)
Interest Debt Per Share0.380.270.33
Revenue Per Share2.412.171.12

Denali Therapeutics Upcoming Company Events

As portrayed in its financial statements, the presentation of Denali Therapeutics' financial position is often influenced by management's estimates, judgments, and sometimes even manipulations. In the best case, Denali Therapeutics' leadership is honest, while the outside auditors are strict and uncompromising. Whatever the case, investors should always follow all of Denali Therapeutics' public filing events to personally review all filings and be reasonable and skeptical to interpret all of the financial statements of Denali Therapeutics. Please utilize our Beneish M Score to check the likelihood of Denali Therapeutics' management manipulating its earnings.
26th of February 2024
Upcoming Quarterly Report
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13th of May 2024
Next Financial Report
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31st of December 2023
Next Fiscal Quarter End
View
26th of February 2024
Next Fiscal Year End
View
30th of September 2023
Last Quarter Report
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31st of December 2022
Last Financial Announcement
View

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Align your risk with return expectations

By capturing your risk tolerance and investment horizon Macroaxis technology of instant portfolio optimization will compute exactly how much risk is acceptable for your desired return expectations
When determining whether Denali Therapeutics offers a strong return on investment in its stock, a comprehensive analysis is essential. The process typically begins with a thorough review of Denali Therapeutics' financial statements, including income statements, balance sheets, and cash flow statements, to assess its financial health. Key financial ratios are used to gauge profitability, efficiency, and growth potential of Denali Therapeutics Stock. Outlined below are crucial reports that will aid in making a well-informed decision on Denali Therapeutics Stock:
Check out Denali Therapeutics Analysis, Denali Therapeutics Valuation, Denali Therapeutics Correlation, Denali Therapeutics Hype Analysis, Denali Therapeutics Volatility, Denali Therapeutics Price History and analyze Denali Therapeutics Performance.
For more detail on how to invest in Denali Stock please use our How to Invest in Denali Therapeutics guide.
You can also try the Premium Stories module to follow Macroaxis premium stories from verified contributors across different equity types, categories and coverage scope.
Denali Therapeutics technical stock analysis exercises models and trading practices based on price and volume transformations, such as the moving averages, relative strength index, regressions, price and return correlations, business cycles, stock market cycles, or different charting patterns.
A focus of Denali Therapeutics technical analysis is to determine if market prices reflect all relevant information impacting that market. A technical analyst looks at the history of Denali Therapeutics trading pattern rather than external drivers such as economic, fundamental, or social events. It is believed that price action tends to repeat itself due to investors' collective, patterned behavior. Hence technical analysis focuses on identifiable price trends and conditions. More Info...